Sodium Hydroxide → HCID 410100, compound

HRID 730078Notes

Reaction equation

HRID 730078 reaction equation
C[O:2][C:3]([C:5]1[C:18]2[O:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[O:19])[C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO>[O:19]=[C:10]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[C:18]=2[O:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 470403HCID 470403, compound

Product 1

HCID 410100HCID 410100, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 9-oxo-9H-xanthene-4-carboxylic acid methyl ester 4j (2.0 g, 7.87 mmol) in methanol (30 mL) was added a 3N sodium hydroxide solution (3.2 mL), and the mixture was heated to reflux for 2 h. The solvent was evaporated and the residue was dissolved in water (50 mL). The solution was filtered, acidified with concentrated hydrochloric acid, and a precipitate formed. The solid was separated via filtration, washed with water, and air-dried to yield 1.9 g (quant.) of title compound 5j.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 2 h
  3. customThe solvent was evaporated
  4. dissolutionthe residue was dissolved in water (50 mL)
  5. filtrationThe solution was filtered
  6. customa precipitate formed
  7. customThe solid was separated via filtration
  8. washwashed with water
  9. customair-dried

Sources & evidence

ORD record
ord-1ab70151d2ef4b0092aad611dc94e862
Source dataset
uspto-grants-2009_09
Patent number
US07582650B2

Reaction notes

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