Sodium Hydroxide → HCID 410100, compound

Participants

Reaction Steps

To a suspension of 9-oxo-9H-xanthene-4-carboxylic acid methyl ester 4j (2.0 g, 7.87 mmol) in methanol (30 mL) was added a 3N sodium hydroxide solution (3.2 mL), and the mixture was heated to reflux for 2 h. The solvent was evaporated and the residue was dissolved in water (50 mL). The solution was filtered, acidified with concentrated hydrochloric acid, and a precipitate formed. The solid was separated via filtration, washed with water, and air-dried to yield 1.9 g (quant.) of title compound 5j.

Provenance & Evidence