HCID 15986283, compound → Trifluoroacetic acid

HRID 730081Notes

Reaction equation

[F:1][C:2]([F:31])([F:30])[C:3]([N:5]1[CH:10]2[CH2:11][CH2:12][CH:6]1[CH2:7][C:8](=[C:13]1[C:26]3[CH:25]=[CH:24][CH:23]=[C:22]([C:27]([NH2:29])=[O:28])[C:21]=3[O:20][C:19]3[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:9]2)=[O:4].FC(F)(F)C(N1C2CCC1CC(=C1C3C=CC=C(O)C=3OC3C1=CC=CC=3)C2)=[O:35]>>[CH:10]12[NH:5][CH:6]([CH2:12][CH2:11]1)[CH2:7][C:8](=[C:13]1[C:26]3[CH:25]=[CH:24][CH:23]=[C:22]([C:27]([NH2:29])=[O:28])[C:21]=3[O:20][C:19]3[C:14]1=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:9]2.[C:3]([OH:35])([C:2]([F:31])([F:30])[F:1])=[O:4]

Participants

Reactant 2

HCID 15986283HCID 15986283, compound

HCID 15986542HCID 15986542, compound

Product 2

HCID 6422Trifluoroacetic acid

HCID 15986281HCID 15986281, compound

Procedure

Using an adaptation of the method described in Procedure 5 substituting (+)-9-[8-(2,2,2-trifluoroacetyl)-8-azabicyclo[3.2.1]oct-3-ylidene]-9H-xanthene-4-carboxylic acid amide 36 for 2,2,2-trifluoro-1-[3-(4-hydroxyxanthen-9-ylidene)-8-azabicyclo[3.2.1]oct-8-yl]-ethanone 4a, title compound 37 was obtained as a TFA salt.

Sources & evidence

ORD record: ord-2220e6dd7217455a84461e14aef71612
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582650B2

Reaction notes

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