Trifluoroacetic acid → Trifluoroacetic acid

HRID 730087Notes

Reaction equation

HRID 730087 reaction equation
C(OC([N:8]1[CH:13]2[CH2:14][CH2:15][CH:9]1[CH2:10][C:11](=[C:16]1[C:29]3[CH:28]=[CH:27][CH:26]=[C:25]([C:30](=[O:37])[NH:31][CH2:32][CH2:33][N:34]([CH3:36])[CH3:35])[C:24]=3[O:23][C:22]3[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:12]2)=O)(C)(C)C.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>O>[CH3:35][N:34]([CH3:36])[CH2:33][CH2:32][NH:31][C:30]([C:25]1[C:24]2[O:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:16](=[C:11]3[CH2:10][CH:9]4[NH:8][CH:13]([CH2:14][CH2:15]4)[CH2:12]3)[C:29]=2[CH:28]=[CH:27][CH:26]=1)=[O:37].[C:40]([OH:42])([C:39]([F:44])([F:43])[F:38])=[O:41]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57833619HCID 57833619, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 15986362HCID 15986362, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Compound 2m was treated with a 95:5 mixture of trifluoroacetic acid:water at rt, and the mixture was lyophilized, yielding the title compound 15 as a TFA salt.

Workup

  1. customat rt

Sources & evidence

ORD record
ord-fcef566eab4144a8970dc7b1e1f58560
Source dataset
uspto-grants-2009_09
Patent number
US07582650B2

Reaction notes

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