反应详情

The crude 5-bromo-2-[2-(3-methoxy-2-methylphenyl)-ethyl]-benzoic acid methyl ester 6 was stirred with 50% KOH solution (5 mL), water (30 mL), methanol (12 mL), and THF (30 mL), heated at reflux temperature for three hours and concentrated in vacuo to remove the organic solvents. The resultant aqueous suspension was acidified using 1.0 N HCl solution and filtered. The filtercake was dried over night to give the benzoic acid 7 as a white solid, 4.74 g; 98% yield.

1. temperatureheated
2. temperatureat reflux temperature for three hours
3. concentrationconcentrated in vacuo
4. customto remove the organic solvents
5. filtrationfiltered
6. customThe filtercake was dried over night