反应详情

温度

150 °C

A mixture of 8-bromo-2-methoxy-1-methyl-11,12-dihydro-6H-dibenzo [a,e]cycloocten-5-one 12 (1.0 g: 2.9 mmol), acetic acid and selenium dioxide (0.64 g; 5.8 mmol) was stirred at 150° C. for 2 hr, cooled to room temperature, diluted with dichloromethane and filtered through silica gel to remove the suspended solids. The filtrate was evaporated to dryness. The residue was heated in ethyl acetate and crystallized by adding hexane to give compound 13 as grey needles, 0.71 g, 68% yield.

1. temperaturecooled to room temperature
2. filtrationfiltered through silica gel
3. customto remove the suspended solids
4. customThe filtrate was evaporated to dryness
5. temperatureThe residue was heated in ethyl acetate
6. customcrystallized
7. additionby adding hexane