Phenyl isocyanate → HCID 21079259, compound

HRID 730184Notes

Reaction equation

HRID 730184 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][C:11]1[C:19]2[C:14](=[CH:15][C:16]([Cl:26])=[C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:18]=2)[N:13]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[N:12]=1>O1CCCC1>[Cl:26][C:16]1[CH:15]=[C:14]2[C:19]([C:11]([NH:10][C:8]([NH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[O:9])=[N:12][N:13]2[CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])=[CH:18][C:17]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 21079252HCID 21079252, compound

Product 1

HCID 21079259HCID 21079259, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Stage 1: 39 □l of phenyl isocyanate are added to a solution of 102.2 mg of 3-amino-5-phenyl-6-chloro-1-[(2-trimethylsilylethoxy)methyl]indazole in 2.5 cm3 of tetrahydrofuran. The reaction medium is stirred at ambient temperature for 24 hours and is then evaporated. Purification of the crude product by chromatography on silica (eluant: methylene chloride/acetone (98/2, v/v)) makes it possible to obtain 122.5 mg of 1-[6-chloro-5-phenyl-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-3-yl]-3-phenylurea (colorless solid).

Workup

  1. customis then evaporated
  2. customPurification of the crude product by chromatography on silica (eluant

Sources & evidence

ORD record
ord-7213a692982e4d668e5c1a1510d7577c
Source dataset
uspto-grants-2009_09
Patent number
US07582669B2

Reaction notes

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