Methyl acetimidate → HCID 178465587, compound

HRID 730187Notes

Reaction equation

HRID 730187 reaction equation
[C:1](=[NH:5])(OC)[CH3:2].[NH2:6][C:7]1[C:15]2[C:10](=[CH:11][C:12]([Cl:22])=[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:14]=2)[NH:9][N:8]=1>C(#N)C.C(O)(=O)C>[Cl:22][C:12]1[CH:11]=[C:10]2[C:15]([C:7]([NH:6][C:1](=[NH:5])[CH3:2])=[N:8][NH:9]2)=[CH:14][C:13]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 2

HCID 26888Methyl acetimidateHCID 223196013-amino-6-chloro-5-phenyl-1H-indazole

Product 1

HCID 178465587HCID 178465587, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6342AcetonitrileSolvent

Procedure

33 mg of methyl acetimidate are added to 50 mg of 3-amino-6-chloro-5-phenyl-1H-indazole in 3 ml of acetonitrile and 12 mg of acetic acid. The reaction is placed under microwave radiation at 180° C. for 5 min. After the usual treatments and purification through silica, 35 mg of N-(6-chloro-5-phenyl-1H-indazol-3-yl)acetamidine are obtained.

Workup

  1. customAfter the usual treatments and purification through silica, 35 mg of N-(6-chloro-5-phenyl-1H-indazol-3-yl)acetamidine
  2. customare obtained

Sources & evidence

ORD record
ord-3ea82e34c2b845758dad8ccb830fa13f
Source dataset
uspto-grants-2009_09
Patent number
US07582669B2

Reaction notes

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