Dimethylamine tetrahydrofuran → Benzo[b]thiophene-2-sulfonic acid {2-[5-(2-dimethylaminoethanesulfonyl)-2-methoxybenzenesulfonylamino]phenyl}-amide

HRID 730224Notes

Reaction equation

HRID 730224 reaction equation
[CH:1]([S:3]([C:6]1[CH:7]=[CH:8][C:9]([O:35][CH3:36])=[C:10]([S:12]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH:22][S:23]([C:26]2[S:30][C:29]3[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=3[CH:27]=2)(=[O:25])=[O:24])(=[O:14])=[O:13])[CH:11]=1)(=[O:5])=[O:4])=[CH2:2].[NH:37]([CH3:39])[CH3:38].C1COCC1>C1COCC1>[CH3:38][N:37]([CH3:39])[CH2:2][CH2:1][S:3]([C:6]1[CH:7]=[CH:8][C:9]([O:35][CH3:36])=[C:10]([S:12]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH:22][S:23]([C:26]2[S:30][C:29]3[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=3[CH:27]=2)(=[O:25])=[O:24])(=[O:13])=[O:14])[CH:11]=1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 22320367Dimethylamine tetrahydrofuranHCID 86605045Benzo[b]thiophene-2-sulfonic acid [2-(5-ethenesulfonyl-2-methoxybenzenesulfonylamino)phenyl] amide

Product 1

HCID 11678864Benzo[b]thiophene-2-sulfonic acid {2-[5-(2-dimethylaminoethanesulfonyl)-2-methoxybenzenesulfonylamino]phenyl}-amide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of benzo[b]thiophene-2-sulfonic acid [2-(5-ethenesulfonyl-2-methoxy-benzenesulfonylamino) -phenyl]-amide (0.5 mmol), as prepared above, in dry THF (10 mL), Me2NH-THF solution (2.5 mL; 2 M Me2NH in THF solution) was added. The resulting reaction mixture was stirred at room temperature for 30 min. After removal of the solvent under vacuum, the residue obtained was purified by flash column chromatography eluting with EtOAc then DCM/methanol (100:2 to 100:10) to give 290 mg of benzo[b]thiophene-2-sulfonic acid {2-[5-(2-dimethylaminoethanesulfonyl)-2-methoxybenzenesulfonylamino]phenyl}-amide. LC: Tr 0.99 min; MS: 610.7 (M+1)+.

Workup

  1. customThe resulting reaction mixture
  2. customAfter removal of the solvent under vacuum
  3. customthe residue obtained
  4. customwas purified by flash column chromatography
  5. washeluting with EtOAc

Sources & evidence

ORD record
ord-4bba2c06ef334f149056f83e7824d33b
Source dataset
uspto-grants-2009_09
Patent number
US07582673B2

Reaction notes

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