反应详情

To a solution of 4-fluoro-2-nitroaniline (1 mmol) in pyridine (3 mL), 5-bromo-2-methoxybenzenesulfonyl chloride (1.2 mmol) was added and the resulting mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with ethyl acetate (20 mL). The contents were washed with 10% aqueous HCl (20 mL) and brine (20 mL), dried over sodium sulfate, and concentrated under vacuum. The residue obtained was purified by column chromatography eluting with hexanes/ethyl acetate to give 223 mg of 5-bromo-N-(4-fluoro-2-nitrophenyl)-2-methoxybenzenesulfonamide.

1. washThe contents were washed with 10% aqueous HCl (20 mL) and brine (20 mL)
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated under vacuum
4. customThe residue obtained
5. customwas purified by column chromatography
6. washeluting with hexanes/ethyl acetate