Pyridine → HCID 57834521, compound

HRID 730245Notes

Reaction equation

HRID 730245 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[S:14][C:15]([S:17](Cl)(=[O:19])=[O:18])=[CH:16][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[NH:28][S:29]([C:32]1[S:36][C:35]2[CH:37]=[CH:38][CH:39]=[CH:40][C:34]=2[CH:33]=1)(=[O:31])=[O:30].N1C=CC=CC=1>C(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[S:14][C:15]([S:17](=[O:19])(=[O:18])[NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[NH:28][S:29]([C:32]3[S:36][C:35]4[CH:37]=[CH:38][CH:39]=[CH:40][C:34]=4[CH:33]=3)(=[O:31])=[O:30])=[CH:16][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 86240018Benzo[b]thiophene-2-sulfonic acid (2-aminophenyl)amideHCID 86605048HCID 86605048, compound

Product 1

HCID 57834521HCID 57834521, compoundYield 312.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[2-(Benzo[b]thiophene-2-sulfonylamino) -phenylsulfamoyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (280 mg) was prepared by using 2-chlorosulfonyl-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (0.049 g, 0.148 mmol) and benzo[b]thiophene-2-sulfonic acid (2-amino-phenyl)-amide (0.045 g, 0.148 mmol, prepared as in Example 1) using pyridine in DCM following procedure as in Example 2.

Sources & evidence

ORD record
ord-5d8637c1fbea4b888758beea0a279c93
Source dataset
uspto-grants-2009_09
Patent number
US07582673B2

Reaction notes

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