[1-[[[2-(Cyclohexylcarbonyl)phenyl]amino]carbonyl]hydrazino]-acetic acid ethyl ester → (5-Cyclohexyl-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl)-acetic acid ethyl ester

Participants

Reaction Steps

[1-[[[2-(Cyclohexylcarbonyl)phenyl]amino]carbonyl]hydrazino]-acetic acid ethyl ester (20 mg) was dissolved in TFA (0.2 mL) and aged for about 15 min. HPLC analysis at this point revealed the disappearance of the signal @ 10.5 min corresponding to starting material, and the appearance of a signal @ 11.01 min corresponding to product. This material was characterized by comparison of the HPLC traces with that of an authentic sample.

Provenance & Evidence