[1-[[[2-(Cyclohexylcarbonyl)phenyl]amino]carbonyl]hydrazino]-acetic acid ethyl ester → (5-Cyclohexyl-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl)-acetic acid ethyl ester

HRID 730396Notes

Reaction equation

HRID 730396 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][N:6]([C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:17]([CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)=O)=[O:9])[NH2:7])[CH3:2]>C(O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4](=[O:25])[CH2:5][N:6]1[C:8](=[O:9])[NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[N:7]1)[CH3:2]

Participants

3

Reactant 1

HCID 16225984[1-[[[2-(Cyclohexylcarbonyl)phenyl]amino]carbonyl]hydrazino]-acetic acid ethyl ester

Product 1

HCID 135489492(5-Cyclohexyl-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl)-acetic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

[1-[[[2-(Cyclohexylcarbonyl)phenyl]amino]carbonyl]hydrazino]-acetic acid ethyl ester (20 mg) was dissolved in TFA (0.2 mL) and aged for about 15 min. HPLC analysis at this point revealed the disappearance of the signal @ 10.5 min corresponding to starting material, and the appearance of a signal @ 11.01 min corresponding to product. This material was characterized by comparison of the HPLC traces with that of an authentic sample.

Workup

  1. custom@ 10.5 min
  2. waitthe appearance of a signal @ 11.01 min corresponding to product

Sources & evidence

ORD record
ord-2941b287c00d42d8996c56efdf09fd72
Source dataset
uspto-grants-2009_09
Patent number
US07582753B2

Reaction notes

Loading…