反应详情

温度

-5 °C

To a cold (˜0° C.) solution of K2CO3 (31.2 g, 225 mmol, ) in water (125 mL) was added N, O-dimethylhydroxylamine hydrochloride (10 g, 100 mmol) and toluene (125 mL). The reaction mixture was further cooled to −5° C. and chloroacetyl chloride (10 mL, 125 mmol, )was added slowly under vigorous agitation. The reaction mixture was then warmed to ambient temperature over 45 min and analyzed by GC for completion. The layers were separated and the aqueous layer was extracted with toluene (3×50 mL). The combined organic layers were concentrated to a solid residue. The residue was dissolved in anhydrous THF (200 mL) cooled to ˜0° C. To the reaction mixture was then added a solution of the cyclopentylmagnesium chloride (60 mL, 2M in diethyl ether), drop-wise, maintaining the temperature at less than about 5° C. The resulting solution was then warmed to ambient temperature over a period of ˜1 hr and then slowly quenched into a cold 3N HCl (100 mL, ). The resulting mixture was then aged for ˜30 min. The layers were separated and the aqueous layer extracted with MTBE (50 mL). The combined organic layers were washed with brine (50 mL), dried over MgSO4 and concentrated to dryness to yield the title compound as a crude product, as a yellow liquid.

1. temperatureThe reaction mixture was then warmed to ambient temperature over 45 min
2. customThe layers were separated
3. extractionthe aqueous layer was extracted with toluene (3×50 mL)
4. concentrationThe combined organic layers were concentrated to a solid residue
5. dissolutionThe residue was dissolved in anhydrous THF (200 mL)
6. temperaturecooled to ˜0° C
7. additionTo the reaction mixture was then added a solution of the cyclopentylmagnesium chloride (60 mL, 2M in diethyl ether)
8. temperaturemaintaining the temperature at less than about 5° C
9. temperatureThe resulting solution was then warmed to ambient temperature over a period of ˜1 hr
10. customslowly quenched into a cold 3N HCl (100 mL, )
11. customThe layers were separated
12. extractionthe aqueous layer extracted with MTBE (50 mL)
13. washThe combined organic layers were washed with brine (50 mL)
14. dry with materialdried over MgSO4
15. concentrationconcentrated to dryness