反应详情

温度

60 °C

A 1 L flask equipped with a magnetic stir bar and heating mantle was charged with [3-(5-oxo-2,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester (60.0 g, 0.22 mol) and EtOH (800 mL). The resulting suspension was then treated with HCl gas (31 g, 0.86 mol) at ambient temperature over 20 minutes. The reaction mixture was then heated to 60° C., until starting material was consumed (1.5 h). The reaction mixture was cooled in an ice-bath and the resulting solid was collected via vacuum filtration. The filter pad was washed with EtOH (75 mL) and air dried to yield the title compound as an off white solid.

1. customA 1 L flask equipped with a magnetic stir bar
2. temperatureheating mantle
3. customwas consumed (1.5 h)
4. temperatureThe reaction mixture was cooled in an ice-bath
5. filtrationthe resulting solid was collected via vacuum filtration
6. washThe filter pad was washed with EtOH (75 mL) and air
7. customdried