2,6-Dimethylmorpholine → HCID 69062272, compound

HRID 730411Notes

Reaction equation

HRID 730411 reaction equation
[C:1]([C:3]1[C:11]2[C:6](=[N:7][C:8]([CH3:13])=[CH:9][C:10]=2[CH3:12])[N:5]([CH:14]2[C:22]3[C:17](=[C:18]([O:25][CH3:26])[C:19]([O:23][CH3:24])=[CH:20][CH:21]=3)[CH2:16][CH2:15]2)[C:4]=1/[CH:27]=[CH:28]/[C:29]([NH:31][CH:32]1[CH2:37][CH2:36]OC(C)(C)C1)=[O:30])#[N:2].C(C1C2C(=NC(C)=CC=2C)N(C2C[C:60]3C(=CC=[C:58](OC)[C:59]=3[O:62]C)C2)C=1/C=C/C(O)=O)#N.CC1OC(C)CNC1>>[CH3:26][O:25][C:18]1[C:19]([O:23][CH3:24])=[CH:20][CH:21]=[C:22]2[C:17]=1[CH2:16][CH2:15][CH:14]2[N:5]1[C:6]2=[N:7][C:8]([CH3:13])=[CH:9][C:10]([CH3:12])=[C:11]2[C:3]([C:1]#[N:2])=[C:4]1/[CH:27]=[CH:28]/[C:29]([N:31]1[CH2:32][CH:37]([CH3:36])[O:62][CH:59]([CH3:60])[CH2:58]1)=[O:30]

Participants

4

Reactant 3

HCID 1108622,6-DimethylmorpholineHCID 69060441HCID 69060441, compoundHCID 69063313HCID 69063313, compound

Product 1

HCID 69062272HCID 69062272, compound

Procedure

In the same manner described in (4) of Example 2, 1-(4,5-dimethoxy-2,3-dihydro-1H-inden-1-yl)-2-[(E)-3.-(2,6-dimethyl-4-morpholinyl)-3-oxo-1-propenyl]-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile was synthesized from (E)-3-[3-cyano-1-(4,5-dimethoxy-2,3-dihydro-1H-inden-2-yl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-propenoic acid and 2,6-dimethylmorpholine.

Sources & evidence

ORD record
ord-decdd6be9da242f88977da4664204886
Source dataset
uspto-grants-2009_09
Patent number
US07582651B2

Reaction notes

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