4-Aminopyridine → HCID 69058012, compound

HRID 730413Notes

Reaction equation

HRID 730413 reaction equation
C(C1[C:11]2[C:6](=[N:7][C:8](CC)=[CH:9][C:10]=2CC)N(C2C3C(=CC=CC=3)CC2)C=1/C=C/C(NC1CCOC(C)(C)C1)=O)#N.[C:38]([C:40]1[C:48]2[C:43](=[N:44][C:45]([CH2:51][CH3:52])=[CH:46][C:47]=2[CH2:49][CH3:50])[N:42]([CH:53]2[C:61]3[C:56](=[CH:57][CH:58]=[CH:59][CH:60]=3)[CH2:55][CH2:54]2)[C:41]=1/[CH:62]=[CH:63]/[C:64]([NH:66]C1C=NC=CC=1)=[O:65])#[N:39].C(C1C2C(=NC(CC)=CC=2CC)N(C2C3C(=CC=CC=3)CC2)C=1/C=C/C(O)=O)#N.NC1C=CN=CC=1>>[C:38]([C:40]1[C:48]2[C:43](=[N:44][C:45]([CH2:51][CH3:52])=[CH:46][C:47]=2[CH2:49][CH3:50])[N:42]([CH:53]2[C:61]3[C:56](=[CH:57][CH:58]=[CH:59][CH:60]=3)[CH2:55][CH2:54]2)[C:41]=1/[CH:62]=[CH:63]/[C:64]([NH:66][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][CH:11]=1)=[O:65])#[N:39]

Participants

5

Reactant 4

HCID 17274-AminopyridineHCID 69055758HCID 69055758, compoundHCID 69057802HCID 69057802, compoundHCID 69060025HCID 69060025, compound

Product 1

HCID 69058012HCID 69058012, compound

Procedure

In the same manner described in (4) of Example 2, (E)-3-[3-cyano-1-(2,3-dihydro-1H-inden-1-yl)-4,6-diethyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-N-(3-pyridinyl)-2-propenamide was synthesized from (E)-3-[3-cyano-1-(2,3-dihydro-1H-inden-1-yl)-4,6-diethyl-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-propenoic acid and 4-aminopyridine.

Sources & evidence

ORD record
ord-4db70cafa7cd48379969349ae5bce6d6
Source dataset
uspto-grants-2009_09
Patent number
US07582651B2

Reaction notes

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