4,4'-Difluorobenzophenone → N-[Bis(4-fluorophenyl)methyl]formamide

HRID 730429Notes

Reaction equation

HRID 730429 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=O)=[CH:4][CH:3]=1.[CH:17]([O-:19])=O.[NH4+:20]>O>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([NH:20][CH:17]=[O:19])[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 95824,4'-DifluorobenzophenoneHCID 2723923Ammonium formate

Product 1

HCID 25126459N-[Bis(4-fluorophenyl)methyl]formamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
170 °C

Procedure

A mixture of 4,4′-difluorobenzophenone (15.0 g, 68.7 mmol) and ammonium formate (35.3 g, 559 mmol) was stirred at 170° C. for 10 hours. The reaction solution was poured into water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to give the objective product as a solid material.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-eb2c72aa499245f4bd326ccde6b7d88e
Source dataset
uspto-grants-2009_09
Patent number
US07582651B2

Reaction notes

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