Tetrahydrofuran → HCID 57833622, compound

HRID 730451Notes

Reaction equation

HRID 730451 reaction equation
[C:1]([C:3]1[C:11]2[C:6](=[N:7][C:8]([CH3:13])=[CH:9][C:10]=2[CH3:12])[N:5]([C@@H:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:17][CH2:16][CH2:15]2)[C:4]=1/[CH:24]=[CH:25]/[C:26]([NH:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=1)=[O:27])#[N:2].C1COCC1>[C].[Pd].CO>[C:1]([C:3]1[C:11]2[C:6](=[N:7][C:8]([CH3:13])=[CH:9][C:10]=2[CH3:12])[N:5]([C@@H:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:17][CH2:16][CH2:15]2)[C:4]=1[CH2:24][CH2:25][C:26]([NH:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=1)=[O:27])#[N:2]

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 9935997HCID 9935997, compound

Product 1

HCID 57833622HCID 57833622, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A mixed solution of (2E)-3-{3-cyano-4,6-dimethyl-1-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-N-(3,4-dimethoxyphenyl)prop-2-enamide (170 mg, 0.336 mmol), 10% palladium carbon (20 mg), THF (3 ml) and methanol (3 ml) was stirred under hydrogen atmosphere for 4 hours. Insolubles were filtrated off and the filtrate was concentrated to give the objective product as a solid material.

Workup

  1. filtrationInsolubles were filtrated off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-0eb3cdb2438c42c6a23c925c500a53ce
Source dataset
uspto-grants-2009_09
Patent number
US07582651B2

Reaction notes

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