Phosphoric Acid → [2-(1-benzyl-2-oxo-2,3-dihydro-1H-indol-4-yloxy)-ethyl]-methyl-carbamic acid tert-butyl ester

HRID 730579Notes

Reaction equation

HRID 730579 reaction equation
[C:1]([O:5][C:6](=[O:29])[N:7]([CH2:9][CH2:10][O:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:13]=1[C:14](Br)=[CH:15][N:16]2[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH3:8])([CH3:4])([CH3:3])[CH3:2].P(=O)(O)(O)[OH:31]>>[C:1]([O:5][C:6](=[O:29])[N:7]([CH2:9][CH2:10][O:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:13]=1[CH2:14][C:15](=[O:31])[N:16]2[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH3:8])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 1004Phosphoric AcidHCID 57834989[2-(1-benzyl-3-bromo-1H-indol-4-yloxy)-ethyl]-methyl-carbamic acid tert-butyl ester

Product 1

HCID 57834977[2-(1-benzyl-2-oxo-2,3-dihydro-1H-indol-4-yloxy)-ethyl]-methyl-carbamic acid tert-butyl ester

Procedure

[2-(1-Benzyl-3-bromo-1H-indol-4-yloxy)-ethyl]-methyl-carbamic acid tert-butyl ester was treated with phosphoric acid using the procedure of step 4 of Example 6 to provide [2-(1-benzyl-2-oxo-2,3-dihydro-1H-indol-4-yloxy)-ethyl]-methyl-carbamic acid tert-butyl ester.

Sources & evidence

ORD record
ord-7d94f7e9a75440b6b0b9e45363fd6539
Source dataset
uspto-grants-2009_09
Patent number
US07582760B2

Reaction notes

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