Triethylamine → HCID 16124653, compound

HRID 730655Notes

Reaction equation

HRID 730655 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:29](O)=[O:30])[CH2:19][C:20]3[CH:25]=[C:24]([CH3:26])[C:23]([OH:27])=[C:22]([CH3:28])[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:32]=[CH:33][CH:34]=[CH:35][C:4]=2[NH:3]1.C(N(CC)CC)C.[NH:43]1[CH2:48][CH2:47][CH:46]([N:49]2[CH2:54][CH2:53][S:52](=[O:55])[CH2:51][CH2:50]2)[CH2:45][CH2:44]1>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:19][C:20]3[CH:21]=[C:22]([CH3:28])[C:23]([OH:27])=[C:24]([CH3:26])[CH:25]=3)[C:29](=[O:30])[N:43]3[CH2:44][CH2:45][CH:46]([N:49]4[CH2:50][CH2:51][S:52](=[O:55])[CH2:53][CH2:54]4)[CH2:47][CH2:48]3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:32]=[CH:33][CH:34]=[CH:35][C:4]=2[NH:3]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 61555501HCID 61555501, compoundHCID 67273812HCID 67273812, compound

Product 1

HCID 16124653HCID 16124653, compound

Procedure

Prepared analogously to Example 1.21 from 80 mg (0.17 mmol) (R)-2-(4-hydroxy-3,5-dimethyl-phenyl)-1-carboxy-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate, 77 μL (0.55 mmol) triethylamine and 47 mg (0.17 mmol) 4-piperidin-4-yl-thiomorpholine-1-oxide (used as the bis-hydrochloride salt).

Sources & evidence

ORD record
ord-041529b3ba0a44b582e35acd738dac77
Source dataset
uspto-grants-2009_09
Patent number
US07582625B2

Reaction notes

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