Lithium Hydroxide → HCID 135540807, compound

HRID 730664Notes

Reaction equation

[O:1]=[C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][N:10]([C:13]([O:15][C@H:16]([CH2:37][C:38]3[CH:43]=[C:42]([CH3:44])[C:41]([OH:45])=[C:40]([CH3:46])[CH:39]=3)[C:17]([N:19]3[CH2:24][CH2:23][CH:22]([N:25]4[CH2:30][CH2:29][N:28]([CH2:31][C:32]([O:34]CC)=[O:33])[CH2:27][CH2:26]4)[CH2:21][CH2:20]3)=[O:18])=[O:14])[CH2:9][CH2:8]2)[N:5]=[C:4]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)[NH:3]1.[Li+].[OH-]>>[O:1]=[C:2]1[N:6]([CH:7]2[CH2:8][CH2:9][N:10]([C:13]([O:15][C@H:16]([CH2:37][C:38]3[CH:43]=[C:42]([CH3:44])[C:41]([OH:45])=[C:40]([CH3:46])[CH:39]=3)[C:17]([N:19]3[CH2:24][CH2:23][CH:22]([N:25]4[CH2:26][CH2:27][N:28]([CH2:31][C:32]([OH:34])=[O:33])[CH2:29][CH2:30]4)[CH2:21][CH2:20]3)=[O:18])=[O:14])[CH2:11][CH2:12]2)[N:5]=[C:4]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)[NH:3]1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 135540803HCID 135540803, compound

Product 1

HCID 135540807HCID 135540807, compound

Procedure

Prepared analogously to Example 2.12 from 38 mg (0.05 mmol) (R)-2-[4-(4-ethoxycarbonylmethyl-piperazin-1-yl)-piperidin-1-yl]-1-(4-hydroxy-3,5-dimethyl-benzyl)-2-oxo-ethyl 4-(5-oxo-3-phenyl-4,5-dihydro-1,2,4-triazol-1-yl)-piperidine-1-carboxylate and 2.1 mg (0.09 mmol) LiOH.

Sources & evidence

ORD record: ord-9c5a7b3179bc404386336caac2450968
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582625B2

Reaction notes

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