Piperazine → 1-(3,5-Dichloropyridin-2-yl)piperazine

HRID 730713Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[C:13]([Cl:14])=[CH:12][C:11]([Cl:15])=[CH:10][N:9]=1>>[Cl:14][C:13]1[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=[C:11]([Cl:15])[CH:12]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 27666Pyridine, 2,3,5-trichloro-

Product 1

HCID 27714311-(3,5-Dichloropyridin-2-yl)piperazine

Procedure

Piperazine (256 mg, 3.0 mmol, Aldrich) and 2,3,5-trichloropyridine (364 mg, 20 mmol, Aldrich) were reacted under the conditions of Example 3a to give the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 232 (M+1).

Sources & evidence

ORD record: ord-4627725fccc3402ba3478fde3aa299fb
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582761B2

Reaction notes

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