Hydrochloric Acid → Piperidine, 4-methoxy-4-phenyl-, hydrochloride (1:1)

Participants

Reaction Steps

A mixture of the ester from step (b) above (8.6g) and saturated solution of hydrogen chloride in EtOAc (100 mL) was stirred at room temperature for 1 h. The solvent was removed in vacuo and the residue was washed with EtOAc, and dried in vacuo to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 192 (M+1).

Provenance & Evidence