Hydrochloric Acid → Piperidine, 4-methoxy-4-phenyl-, hydrochloride (1:1)

HRID 730741Notes

Reaction equation

HRID 730741 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([O:20][CH3:21])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][O:20][C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22629553HCID 22629553, compound

Product 1

HCID 54606281Piperidine, 4-methoxy-4-phenyl-, hydrochloride (1:1)

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of the ester from step (b) above (8.6g) and saturated solution of hydrogen chloride in EtOAc (100 mL) was stirred at room temperature for 1 h. The solvent was removed in vacuo and the residue was washed with EtOAc, and dried in vacuo to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 192 (M+1).

Workup

  1. customThe solvent was removed in vacuo
  2. washthe residue was washed with EtOAc
  3. customdried in vacuo

Sources & evidence

ORD record
ord-97f8c414d8b74709b8981a755edbd2c7
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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