Diisopropylethylamine → HCID 57835162, compound

HRID 730743Notes

Reaction equation

HRID 730743 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:10]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[N:11][CH:12]=[N:13][CH:14]=1.[Br:21][C:22]1[C:30]2[N:29]=[C:28](Cl)[NH:27][C:26]=2[CH:25]=[C:24]([C:32]([F:35])([F:34])[F:33])[CH:23]=1.C(N(CC)C(C)C)(C)C>>[Br:21][C:22]1[C:30]2[N:29]=[C:28]([N:18]3[CH2:17][CH2:16][N:15]([C:10]4[C:9]([Cl:8])=[CH:14][N:13]=[CH:12][N:11]=4)[CH2:20][CH2:19]3)[NH:27][C:26]=2[CH:25]=[C:24]([C:32]([F:35])([F:34])[F:33])[CH:23]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 115945854-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazoleHCID 674017991-(5-Chloropyrimidin-4-yl)piperazine trifluoroacetic acid salt

Product 1

HCID 57835162HCID 57835162, compound

Procedure

The reaction of 1-(5-chloropyrimidin-4-yl)piperazine trifluoroacetic acid salt (0.414 g, 0.97 mmol, Example 33d), 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole (0.29 g, 0.97 mmol, Example 9b) and N,N-diisopropylethylamine (0.5 mL, 2.91 mmol, Aldrich) under the conditions of Example 1d gave the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 461 (M+1).

Sources & evidence

ORD record
ord-da61e9061a4247b3b63fcd453140f514
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

Loading…