HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 2-(1-piperazinyl)-3-Pyridinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Fluoro-3-(hydroxymethyl)pyridine | HCID 14761461 | — |
| Product | 2-(1-piperazinyl)-3-Pyridinemethanol | HCID 67400406 | — |
Reaction Steps
A mixture of (2-fluoro-pyridin-3-yl)methanol (1 g, 8 mmol, Asymchem), piperazine (1.3 g, 15 mmol) and N,N-diisopropylethylamine (1 mL, 5.8 mmol, Aldrich) was reacted under the conditions of Example 43a to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 194 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-402d54a225dd4d90b96df97135655543 |
| Source note | uspto-grants-2009_09 |