Piperazine → 2-(1-piperazinyl)-3-Pyridinemethanol

HRID 730753Notes

Reaction equation

HRID 730753 reaction equation
F[C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(N(CC)C(C)C)(C)C>>[N:10]1([C:2]2[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 81531DiisopropylethylamineHCID 147614612-Fluoro-3-(hydroxymethyl)pyridine

Product 1

HCID 674004062-(1-piperazinyl)-3-Pyridinemethanol

Procedure

A mixture of (2-fluoro-pyridin-3-yl)methanol (1 g, 8 mmol, Asymchem), piperazine (1.3 g, 15 mmol) and N,N-diisopropylethylamine (1 mL, 5.8 mmol, Aldrich) was reacted under the conditions of Example 43a to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 194 (M+1).

Workup

  1. customwas reacted under the conditions of Example 43a

Sources & evidence

ORD record
ord-402d54a225dd4d90b96df97135655543
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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