4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole → HCID 178519686, compound

HRID 730755Notes

Reaction equation

HRID 730755 reaction equation
[N:1]1([C:7]2[C:12]([CH2:13][OH:14])=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Br:15][C:16]1[C:24]2[N:23]=[C:22](Cl)[NH:21][C:20]=2[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[CH:17]=1>>[Br:15][C:16]1[C:24]2[NH:23][C:22]([N:4]3[CH2:3][CH2:2][N:1]([C:7]4[C:12]([CH2:13][OH:14])=[CH:11][CH:10]=[CH:9][N:8]=4)[CH2:6][CH2:5]3)=[N:21][C:20]=2[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[CH:17]=1

Participants

3

Reactant 2

HCID 115945854-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazoleHCID 674004062-(1-piperazinyl)-3-Pyridinemethanol

Product 1

HCID 178519686HCID 178519686, compound

Procedure

(2-Piperazin-1-ylpyridin-3-yl)methanol (0.48 g, 2.5 mmol, Example 46a) reacted with 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole (0.60 g, 2 mmol, Example 6b) under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 456 (M+1).

Sources & evidence

ORD record
ord-48c8977adccb4edbba00350590e427d3
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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