HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-chloro-4-nitro-6-(trifluoromethyl)-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-Nitro-6-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 11630155 | — |
| Product | 2-chloro-4-nitro-6-(trifluoromethyl)-1H-benzoimidazole | HCID 11637534 | — |
Reaction Steps
The benzoimidazol-2-one from step (b) above (1.8 g, 7.3 mmol) reacted with POCl3 under the conditions of Example 1c to give the title compound as a yellow solid. MS (ESI, pos. ion) m/z: 266 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-88985aa2ac8e4a429fb93afd0ea8f372 |
| Source note | uspto-grants-2009_09 |