4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole → HCID 178461521, compound

HRID 730790Notes

Reaction equation

HRID 730790 reaction equation
[Br:1][C:2]1[C:10]2[N:9]=[C:8](Cl)[NH:7][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.[Cl:16][C:17]1[C:18]([N:23]2[CH2:28][CH2:27][NH:26][C@H:25]([CH3:29])[CH2:24]2)=[N:19][CH:20]=[CH:21][CH:22]=1>>[Br:1][C:2]1[C:10]2[NH:9][C:8]([N:26]3[CH2:27][CH2:28][N:23]([C:18]4[C:17]([Cl:16])=[CH:22][CH:21]=[CH:20][N:19]=4)[CH2:24][C@H:25]3[CH3:29])=[N:7][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1

Participants

3

Reactant 2

HCID 115945854-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazoleHCID 11658551(3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine

Product 1

HCID 178461521HCID 178461521, compound

Procedure

4-Bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole (1.2 g, 4 mmol, Example 6b) reacted with (3R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine (0.95 g, 4.5 mmol, Example 74a) under the conditions of Example 3c to give the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 474 (M+1).

Sources & evidence

ORD record
ord-73f472efc2a9467b98680d5e38200745
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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