Phosphorus oxychloride → 1H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)-

HRID 730798Notes

Reaction equation

[Cl:1][C:2]1[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:5]2[NH:6][C:7](=O)[NH:8][C:4]=2[CH:3]=1.O=P(Cl)(Cl)[Cl:18]>>[Cl:18][C:7]1[NH:8][C:4]2[CH:3]=[C:2]([Cl:1])[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:5]=2[N:6]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 673998535-Chloro-6-trifluoromethyl-1,3-dihydro-benzoimidazol-2-one

Product 1

HCID 1785060581H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)-

Procedure

The benzoimidazol-2-one from step (b) above (1.43 g, 6.0 mmol) reacted with POCl3 under the conditions of Example 1c to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 254.9 (M+1).

Sources & evidence

ORD record: ord-18015b71de6d440c97d4878bc8d16039
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582761B2

Reaction notes

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