Acetic Anhydride → N-[4-Bromo-3-(trifluoromethyl)phenyl]acetamide

HRID 730805Notes

Reaction equation

HRID 730805 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:13](=[O:15])[CH3:14])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 678524-Bromo-3-(trifluoromethyl)aniline

Product 1

HCID 697838N-[4-Bromo-3-(trifluoromethyl)phenyl]acetamide

Procedure

A mixture of 4-bromo-3-(trifluoromethyl)phenylamine (7.2 g, 30 mmol, Aldrich) and acetic anhydride (29 mL) was stirred at room temperature for 16 h. The reaction mixture was evaporated in vacuo to give the title product as a white solid which was used in the next step without additional purification. MS (ESI, pos. ion) m/z: 484.0 (M+1).

Workup

  1. customThe reaction mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-3c47c0c6b2ab4eb19b2bde35347fbeda
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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