Hydrochloric Acid → 1-(5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)ethanone hydrochloride

Participants

Reaction Steps

A mixture of 4-(5-acetyl-3-chloro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester from step (c) above (0.65 g, 1.92 mmol) and satd solution of HCl in EtOAc (50 mL) was stirred at room temperature for 4 h. The solution was evaporated in vacuo to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 240 (M+1).

Provenance & Evidence