Hydrochloric Acid → 1-(5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)ethanone hydrochloride

HRID 730818Notes

Reaction equation

HRID 730818 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([Cl:20])=[CH:18][C:17]([C:21](=[O:23])[CH3:22])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CCOC(C)=O>[ClH:20].[Cl:20][C:19]1[CH:18]=[C:17]([C:21](=[O:23])[CH3:22])[CH:16]=[N:15][C:14]=1[N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11631471Tert-butyl 4-(5-acetyl-3-chloropyridin-2-yl)piperazine-1-carboxylate

Product 1

HCID 1210064991-(5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)ethanone hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 4-(5-acetyl-3-chloro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester from step (c) above (0.65 g, 1.92 mmol) and satd solution of HCl in EtOAc (50 mL) was stirred at room temperature for 4 h. The solution was evaporated in vacuo to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 240 (M+1).

Workup

  1. customThe solution was evaporated in vacuo

Sources & evidence

ORD record
ord-c1a4ae23f6c6454d83be80d9312e534e
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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