Nitric Acid → 3-Nitro-5-(trifluoromethyl)pyridin-2-amine

Temperature

0 °C

To a 250-mL, round-bottomed flask was added 5-trifluoromethyl-pyridin-2-ylamine (8.3 g, 51.2 mmol, Matrix Scientific) and H2SO4 (49 mL). The resulting mixture was cooled to 0° C., and HNO3 (8.2 mL) was added dropwise. The mixture was heated to 80° C. for 48 h, cooled to room temperature and added dropwise into a vigorously stirred ice-water (500 mL). After the addition, the mixture was basified to pH 9 with ION NaOH and extracted with EtOAc (2×500 mL). The combined organic extracts were dried over MgSO4 and filtered. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with EtOAc/hexane (1:2) to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 208 (M+1).

1. temperatureThe mixture was heated to 80° C. for 48 h
2. temperaturecooled to room temperature
3. additionAfter the addition
4. extractionextracted with EtOAc (2×500 mL)
5. dry with materialThe combined organic extracts were dried over MgSO4
6. filtrationfiltered
7. customThe solvent was removed in vacuo
8. customthe residue was purified by silica gel column chromatography
9. washeluting with EtOAc/hexane (1:2)

ORD record

ord-d574823645e64fc39ea7f4b9579cf678

Source dataset

uspto-grants-2009_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07582761B2