Piperazine → HCID 86593830, compound

HRID 730831Notes

Reaction equation

HRID 730831 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[NH:12][C:11]2[C:13]([C:21]3[CH:26]=[C:25]([F:27])[C:24]([F:28])=[C:23]([F:29])[CH:22]=3)=[CH:14][C:15]([C:17]([F:20])([F:19])[F:18])=[CH:16][C:10]=2[N:9]=1>>[N:1]1([C:8]2[NH:9][C:10]3[CH:16]=[C:15]([C:17]([F:20])([F:18])[F:19])[CH:14]=[C:13]([C:21]4[CH:26]=[C:25]([F:27])[C:24]([F:28])=[C:23]([F:29])[CH:22]=4)[C:11]=3[N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 178505440HCID 178505440, compound

Product 1

HCID 86593830HCID 86593830, compound

Procedure

Piperazine (429 mg, 4.99 mmol, Aldrich) and 2-chloro-5-trifluoromethyl-7-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole (582 mg, 1.66 mmol, Example 51b) reacted under the conditions of Example 100e to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 401 (M+1).

Sources & evidence

ORD record
ord-8e59e2e0d8d44f638e8139e027a03058
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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