2-chloro-6-(trifluoromethyl)-1H-benzimidazole → HCID 178494603, compound

HRID 730864Notes

Reaction equation

HRID 730864 reaction equation
[Cl:1][C:2]1[C:3]([N:11]2[CH2:16][CH2:15][NH:14][C@H:13]([CH3:17])[CH2:12]2)=[N:4][CH:5]=[C:6]([CH2:8][O:9][CH3:10])[CH:7]=1.Cl[C:19]1[NH:23][C:22]2[CH:24]=[C:25]([C:28]([F:31])([F:30])[F:29])[CH:26]=[CH:27][C:21]=2[N:20]=1>O1CCOCC1>[Cl:1][C:2]1[C:3]([N:11]2[CH2:16][CH2:15][N:14]([C:19]3[NH:20][C:21]4[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:22]=4[N:23]=3)[C@H:13]([CH3:17])[CH2:12]2)=[N:4][CH:5]=[C:6]([CH2:8][O:9][CH3:10])[CH:7]=1

Participants

4

Reactant 2

HCID 3379052-chloro-6-(trifluoromethyl)-1H-benzimidazoleHCID 67400341HCID 67400341, compound

Product 1

HCID 178494603HCID 178494603, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of (3R)-1-(3-chloro-5-methoxymethyl-pyridin-2-yl)-3-methyl-piperazine from step (b) above (153 mg, 0.6 mmol) and 2-chloro-6-trifluoromethyl-1H-benzoimidazole (153 mg, 0.48 mmol, Example 1c) in dioxane (2 mL) reacted under the conditions of Example 3c to give the title compound. MS (ESI, pos. ion) m/z: 440 (M+1).

Workup

  1. customreacted under the conditions of Example 3c

Sources & evidence

ORD record
ord-8d53ca50773047d3885eb7786ec5c1f9
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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