Methylamine → [(5,6-Dichloropyridin-3-yl)methyl](methyl)amine

HRID 730868Notes

Reaction equation

HRID 730868 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]2C(=O)C3C(=CC=CC=3)[C:11]2=O)[CH:5]=[N:6][C:7]=1[Cl:8].CN>CCO>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][NH:10][CH3:11])[CH:5]=[N:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 859654402-(5,6-Dichloro-pyridin-3-ylmethyl)-isoindole-1,3-dione

Product 1

HCID 85663685[(5,6-Dichloropyridin-3-yl)methyl](methyl)amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(5,6-dichloro-pyridin-3-ylmethyl)-isoindole-1,3-dione from step (b) above (307 mg, 1.0 mmol) and methylamine (1.0 mL, 2.0 mmoL, 2.0 M in THF, Aldrich) in EtOH (10 mL) was stirred at room temperature for 4 days. The solvent was removed in vacuo to give the title compound, which was used in the next step without additional purification.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-d017c469903d45a7981b285fe0ac1cfc
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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