HRID730874

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID337905

2-Chloro-6-(trifluoromethyl)-1H-benzimidazole

C8H4ClF3N2

结构：CC(=O)N(C)Cc1cnc(N2CCN[C@H](C)C2)c(Cl)c1

HCID67401544

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N(C)Cc1cnc(N2CCN(c3nc4cc(C(F)(F)F)ccc4[nH]3)[C@H](C)C2)c(Cl)c1

HCID178474701

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 2-chloro-6-trifluoromethyl-1H-benzoimidazole (88 mg, 0.4 mmol, Example 1c) and N-[5-chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-ylmethyl]-N-methyl-acetamide from step (b) above (148 mg, 0.5 mmol) in ethanol (2 mL) reacted under the conditions Example 3c to give the title compound. MS (ESI, pos. ion) m/z: 481 (M+1).

WORKUP

后处理

customreacted under the conditions Example 3c