HRID730877

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID337905

2-Chloro-6-(trifluoromethyl)-1H-benzimidazole

C8H4ClF3N2

HCID67400439

5-Chloro-α,α-dimethyl-6-[(3R)-3-methyl-1-piperazinyl]-3-pyridinemethanol

C13H20ClN3O

PRODUCTS

生成物

结构：C[C@@H]1CN(c2ncc(C(C)(C)O)cc2Cl)CCN1c1nc2cc(C(F)(F)F)ccc2[nH]1

HCID178461528

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 2-chloro-6-trifluoromethyl-1H-benzoimidazole (58 mg, 0.26 mmol, Example 1c) and 2-[5-chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl]-propan-2-ol from step (c) above (90 mg, 0.33 mmol) in ethanol (1 mL) reacted under the conditions of Example 3c to give the title compound. MS (ESI, pos. ion) m/z: 454 (M+1).

WORKUP

后处理

customreacted under the conditions of Example 3c