Phosphorus oxychloride → HCID 178522153, compound

HRID 730886Notes

Reaction equation

HRID 730886 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[C:23]([F:26])[C:24]=1[F:25])[C:5]([NH:7][C:8]1[C:16]2[NH:15][C:14](=O)[NH:13][C:12]=2[CH:11]=[C:10]([C:18]([F:21])([F:20])[F:19])[CH:9]=1)=[O:6].O=P(Cl)(Cl)[Cl:29]>>[Cl:29][C:14]1[NH:15][C:16]2[C:8]([NH:7][C:5](=[O:6])[C:4]3[CH:3]=[C:2]([F:1])[C:24]([F:25])=[C:23]([F:26])[CH:22]=3)=[CH:9][C:10]([C:18]([F:21])([F:20])[F:19])=[CH:11][C:12]=2[N:13]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 865938333,4,5-Trifluoro-N-(2-oxo-6-trifluoromethyl-2,3-dihydro-1H-benzoimidazol-4-yl)-benzamide

Product 1

HCID 178522153HCID 178522153, compound

Procedure

3,4,5-Trifluoro-N-(2-oxo-6-trifluoromethyl-2,3-dihydro-1H-benzoimidazol-4-yl)-benzamide from step (c) above (1.12 g, 3.0 mmol) reacted with POCl3 (5 mL, Aldrich) under the conditions of Example 1c to give the title compound as a white solid. MS (ESI, pos. ion) m/e: 393.7 (M+1), (ESI, neg. ion) m/z: 392 (M−1).

Sources & evidence

ORD record
ord-1ae25bd2dc254675ab0bac35cc66fa98
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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