2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole → HCID 178485547, compound

HRID 730892Notes

Reaction equation

HRID 730892 reaction equation
[CH3:1][NH:2][C:3]([CH:5]1[CH2:10][N:9]([C:11]2[C:16]([Cl:17])=[CH:15][C:14]([CH2:18][OH:19])=[CH:13][N:12]=2)[CH2:8][CH2:7][NH:6]1)=[O:4].Cl[C:21]1[NH:25][C:24]2[CH:26]=[C:27]([C:39]([F:42])([F:41])[F:40])[CH:28]=[C:29]([C:30]3[CH:35]=[C:34]([F:36])[C:33]([F:37])=[C:32]([F:38])[CH:31]=3)[C:23]=2[N:22]=1>CCO>[CH3:1][NH:2][C:3]([CH:5]1[CH2:10][N:9]([C:11]2[C:16]([Cl:17])=[CH:15][C:14]([CH2:18][OH:19])=[CH:13][N:12]=2)[CH2:8][CH2:7][N:6]1[C:21]1[NH:22][C:23]2[C:29]([C:30]3[CH:31]=[C:32]([F:38])[C:33]([F:37])=[C:34]([F:36])[CH:35]=3)=[CH:28][C:27]([C:39]([F:42])([F:40])[F:41])=[CH:26][C:24]=2[N:25]=1)=[O:4]

Participants

4

Reactant 2

HCID 116388672-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazoleHCID 674004794(3-Chloro-5-hydroxymethyl-pyridin-2-yl)-piperazine-2-carboxylic acid methylamide

Product 1

HCID 178485547HCID 178485547, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-(3-chloro-5-hydroxymethyl-pyridin-2-yl)-piperazine-2-carboxylic acid methylamide from step (d) above (114 mg, 0.4 mmol) and 2-chloro-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole (140 mg, 0.4 mmol, Example 51b) in EtOH (1 mL) reacted under the conditions of Example 3c to give the title compound as a white solid. MS ESI, pos. ion) m/e: 599 (M+1).

Workup

  1. customreacted under the conditions of Example 3c

Sources & evidence

ORD record
ord-1e181e8a5de2497aa4dd7bc30b06c829
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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