Methyl 5,6-Dichloronicotinate → HCID 11666200, compound

HRID 730898Notes

Reaction equation

HRID 730898 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8]([Cl:10])[C:7](Cl)=[N:6][CH:5]=1.[CH3:13][C@@H:14]1[CH2:19][NH:18][CH2:17][CH2:16][NH:15]1>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[C:8]([Cl:10])[C:7]([N:18]2[CH2:17][CH2:16][NH:15][C@H:14]([CH3:13])[CH2:19]2)=[N:6][CH:5]=1

Participants

3

Reactant 2

HCID 2782166Methyl 5,6-DichloronicotinateHCID 73304342-Methylpiperazine, (R)-

Product 1

HCID 11666200HCID 11666200, compound

Procedure

5,6-Dichloro-nicotinic acid methyl ester from step (a) above (1.23 g, 6.0 mmol) and (R)-(−)-2-methyl-piperazine (667 mg, 6.6 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound as a white solid. MS ESI, pos. ion) m/e: 270 (M+1).

Sources & evidence

ORD record
ord-c0727fe6bcd84ad189b6bc9c3f1fc25d
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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