HCID 178461540, compound → HCID 178461539, compound

HRID 730901Notes

Reaction equation

HRID 730901 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:37][OH:38])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C:14]2[NH:18][C:17]3[C:19]([C:27]4[CH:32]=[C:31]([F:33])[C:30]([F:34])=[C:29]([F:35])[CH:28]=4)=[CH:20][C:21]([C:23]([F:26])([F:25])[F:24])=[CH:22][C:16]=3[N:15]=2)[C@H:10]([CH3:36])[CH2:9]1>O=[Mn]=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:37]=[O:38])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C:14]2[NH:18][C:17]3[C:19]([C:27]4[CH:28]=[C:29]([F:35])[C:30]([F:34])=[C:31]([F:33])[CH:32]=4)=[CH:20][C:21]([C:23]([F:25])([F:24])[F:26])=[CH:22][C:16]=3[N:15]=2)[C@H:10]([CH3:36])[CH2:9]1

Participants

3

Reactant 1

HCID 178461540HCID 178461540, compound

Product 1

HCID 178461539HCID 178461539, compound

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Procedure

(5-Chloro-6-{(3R)-3-methyl-4-[6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazol-2-yl]-piperazin-1-yl}-pyridin-3-yl)-methanol (110 mg, 0.2 mmol, Example 162) reacted with MnO2 (348 mg, 4.0 mmol, Aldrich) under the conditions of Example 154a to give the title compound as a gum, which is was used in the next step without additional purification. MS ESI, pos. ion) m/e: 554 (M+1).

Sources & evidence

ORD record
ord-02468de205554d6a9aa37b077c43279c
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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