2-Chloro-3-(trifluoromethyl)pyridine → (R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine

HRID 730902Notes

Reaction equation

HRID 730902 reaction equation
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][C@@H:13]1[CH2:18][NH:17][CH2:16][CH2:15][NH:14]1>>[CH3:12][C@H:13]1[NH:14][CH2:15][CH2:16][N:17]([C:2]2[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=2)[CH2:18]1

Participants

3

Reactant 2

HCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 73304342-Methylpiperazine, (R)-

Product 1

HCID 11528875(R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine

Procedure

2-Chloro-3-trifluoromethyl-pyridine (7.26, 40 mmol, TCI-US) and (R)-(−)-2-methyl-piperazine (4.45 g, 44 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound as a gum. MS (ESI, pos. ion) m/e: 246 (M+1).

Sources & evidence

ORD record
ord-dd9ef5ed0cf24bb5b7a6afc1bbcdf39a
Source dataset
uspto-grants-2009_09
Patent number
US07582761B2

Reaction notes

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