HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-(trifluoromethyl)pyridine → (R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-(trifluoromethyl)pyridine | HCID 589833 | — |
| Reactant | 2-Methylpiperazine, (R)- | HCID 7330434 | — |
| Product | (R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine | HCID 11528875 | — |
Reaction Steps
2-Chloro-3-trifluoromethyl-pyridine (7.26, 40 mmol, TCI-US) and (R)-(−)-2-methyl-piperazine (4.45 g, 44 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound as a gum. MS (ESI, pos. ion) m/e: 246 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582761B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-dd9ef5ed0cf24bb5b7a6afc1bbcdf39a |
| Source note | uspto-grants-2009_09 |