Phosphorus oxychloride → HCID 178478308, compound

HRID 730923Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[NH:10][C:9](=O)[NH:8][C:5]2=[N:6][CH:7]=1.O=P(Cl)(Cl)[Cl:14]>>[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([Cl:14])[NH:8][C:5]2=[N:6][CH:7]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 19244136-bromo-3H-imidazo[4,5-b]pyridin-2-ol

Product 1

HCID 178478308HCID 178478308, compound

Procedure

The pyridin-2-one from step (a) above (1 g, 4.7 mmol) reacted with POCl3 under the conditions of Example 1c to give the title compound as a brown solid. MS (ESI, pos. ion) m/z: 232 (M+1).

Sources & evidence

ORD record: ord-837bff41d9c44d2da51615047aa4968b
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582761B2

Reaction notes

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