Potassium Carbonate → HCID 57835406, compound

HRID 730983Notes

Reaction equation

HRID 730983 reaction equation
[CH2:1]([C:3]([C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[C:19]([CH3:24])[CH:18]=1)([C:6]1[S:10][C:9]2[CH:11]=[CH:12][C:13]([O:15][CH3:16])=[CH:14][C:8]=2[CH:7]=1)[CH2:4][CH3:5])[CH3:2].Br[CH2:26][C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:1]([C:3]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:26][C:27](=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29])=[C:19]([CH3:24])[CH:18]=1)([C:6]1[S:10][C:9]2[CH:11]=[CH:12][C:13]([O:15][CH3:16])=[CH:14][C:8]=2[CH:7]=1)[CH2:4][CH3:5])[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 21642BromopinacoloneHCID 57835407HCID 57835407, compound

Product 1

HCID 57835406HCID 57835406, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-[1-Ethyl-1-(5-methoxy-benzo[b]thiophen-2-yl)-propyl]-2-methyl-phenol (7.80 g, 22.9 mmol), 1-bromopinacolone (8.20 g, 45.8 mmol), and K2CO3 (6.32 g, 45.8 mmol) in acetone (100 mL) are reacted analogous to Example 1D to provide the title compound (9.20 g, 92%).

Sources & evidence

ORD record
ord-70f9f86d1e5144dab0275cd384b5ca3b
Source dataset
uspto-grants-2009_09
Patent number
US07582775B2

Reaction notes

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