Sodium Hydroxide → HCID 11753040, compound

HRID 730995Notes

Reaction equation

C[O:2][C:3](=[O:39])[C:4]([NH:7][C:8]([C:10]1[CH:11]=[CH:12][C:13]2[CH:17]=[C:16]([C:18]([CH2:36][CH3:37])([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]([CH2:33][CH3:34])([OH:32])[CH2:30][CH3:31])=[C:23]([CH3:35])[CH:22]=3)[CH2:19][CH3:20])[S:15][C:14]=2[CH:38]=1)=[O:9])([CH3:6])[CH3:5].[OH-].[Na+]>>[CH2:36]([C:18]([C:16]1[S:15][C:14]2[CH:38]=[C:10]([C:8]([NH:7][C:4]([CH3:6])([CH3:5])[C:3]([OH:39])=[O:2])=[O:9])[CH:11]=[CH:12][C:13]=2[CH:17]=1)([C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]([CH2:30][CH3:31])([OH:32])[CH2:33][CH3:34])=[C:23]([CH3:35])[CH:22]=1)[CH2:19][CH3:20])[CH3:37]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 11455687HCID 11455687, compound

Product 1

HCID 11753040HCID 11753040, compoundYield 91%

Procedure

Using the procedure analogous to Example 5, from 2-[(2-{1-Ethyl-1-[4-(2-ethyl-2-hydroxy-butoxy)-3-methyl-phenyl]-propyl}-benzo[b]thiophene-6-carbonyl)-amino]-2-methyl-propionic acid methyl ester, example 30 (0.10 g, 0.18 mmol) and NaOH (0.036 g, 0.90 mmol) to furnish the titled compound (0.088 g, 0.016 mmol, 91%). LC/MS (m/z): calcd. for C31H41NO5S (M+H)+: 540.3; found: 540.3.

Sources & evidence

ORD record: ord-9873c5a9e3404430b988a4c6cffc2040
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07582775B2

Reaction notes

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